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But when scientist Eric Lander looks at this he sees stories. ERIC LANDER (Whitehead Institute/MIT): The genome is a storybook. And you could take it to bed. A Thousand and One Arabian Nights, and read a different story in. ROBERT KRULWICH: This is the story of one of the greatest. DNA. And. now, finally, the . CRAIG VENTER (President, Celera Genomics): We're at the moment. This is what we wanted to do, you know? We're now. examining and interpreting the genetic code. FRANCIS COLLINS (National Human Genome Research Institute): This. ROBERT KRULWICH: And what it's telling us is so surprising and. Fifty percent of the genes in a banana are in. ERIC LANDER: How different are you from a banana? Second Life official website. Second Life is a free 3D virtual world where users can socialize, connect and create using free voice and text chat. Life On The Line Movie TrailerROBERT KRULWICH: I feel.. I feel I can say this with some. ERIC LANDER: You may feel different.. ROBERT KRULWICH: I eat a banana. ERIC LANDER: All the machinery for replicating your DNA, all the. Perhaps more than we could possibly imagine. Which one of us. will get cancer or arthritis or Alzheimer's? Will parents. in the future be able to determine their children's genetic. ERIC LANDER: We've opened a box here that has got a huge amount of. It is the key to understanding disease and in the long. But having opened it, we're also going to be very. ROBERT KRULWICH: Yes, some of the information you are about to. On the other hand, some of it I think. And tonight we will not only report the latest. Human Genome project, you will meet the people who made. And we'd like to have your thoughts. So please, if you will, log on to NOVA's Website—it's. The results will be immediately. Some. people already know Northwestern Mutual can help plan for your children's. Northwestern Mutual Financial Network. And by the Corporation for. Public Broadcasting, and by contributions to your PBS station from viewers like. Thank You. ROBERT KRULWICH: To begin, let's go back four and some billion. That speck did something that has gone. The message has passed from the very first organism. And here is that message contained in this stunning little. DNA. You've seen it in this form, the. DNA, I wondered, . So this here's DNA. ROBERT KRULWICH: Professor Eric Lander is a geneticist at. MIT's Whitehead Institute. ERIC LANDER: It's very, very long strands of molecules, these double. DNA, which, when you get them all together, just look like little. ROBERT KRULWICH: And these strands were literally pulled from. ERIC LANDER: Whoever contributed this DNA, you can tell from this. Alzheimer's disease, you can. And there's. probably about 2. And it's really incredibly unlikely that you can. But that's DNA for you. That apparently is the secret. ROBERT KRULWICH: And already DNA has told us things that no. It turns out that human beings have only twice as. We are such complex and. DNA also. tells us that we are more closely related to worms and to yeast than most of us. Well, if it's DNA, if you. Each step is made up of two chemicals. They come always in pairs, called. C and G, or T and A for short. This is, step by step, a. ROBERT KRULWICH: We're all familiar with this thing, this. ERIC LANDER: .. double helix.. ROBERT KRULWICH: .. First of all, I'm. DNA molecule. Is this, by the way, what it. ERIC LANDER: Well, give or take. I mean, a cartoon version, yeah. ROBERT KRULWICH: Cartoon version? ERIC LANDER: A little like that or so, yeah. ROBERT KRULWICH: So there are.. ERIC LANDER: Oh yes, stuck in the nucleus of your cell. ROBERT KRULWICH: Now how small is this, if in a real DNA. ERIC LANDER: Oh golly.. ROBERT KRULWICH: Look at this. He's asking for. help. ERIC LANDER: This distance is about from.. ROBERT KRULWICH: That's one billionth of a meter when it's. ERIC LANDER: Well no, it's curled up some like that but you see it's. You can't curl it up too much because these little negatively. I'm going to break. ROBERT KRULWICH: No, don't break my molecule.. ERIC LANDER: You got this. And then it's folded up like this. And then. those are folded up on top of each other. And so, in fact, if you were to. DNA it would run, oh, I don't know, thousands and. ROBERT KRULWICH: But the main thing about this is the. If I knew it was A and T and C and C and G. G and A.. ERIC LANDER: No, no. It's not G and G, it's G and C. ROBERT KRULWICH: I'm sorry, whatever the rules are of the. I could read each of the individual ladders, I might find. ERIC LANDER: Well, of your children. This is what you pass to your. You know people have known for 2. Well it's because you must pass them something, some instructions. And the only way you pass it to them is in these sentences. ROBERT KRULWICH: And to show you the true power of this. As and Ts and Cs and Gs and the classic double spiral. And. then it starts the mysterious process that creates a healthy new baby. And the. interesting thing is that every human baby, every baby born, is 9. That was partly because in. It took 1. 0 years. Another 1. 0 years. Huntington's disease. Fifteen years to find one of the. One letter at a time, painfully. ROBERT WATERSTON: One, two, three, four, five.. ROBERT KRULWICH: .. ROBERT WATERSTON (DNA mapping pioneer): .. Cs in a row. NARRATOR: .. Robert Waterston, a pioneer in mapping DNA, to show us the way. ROBERT WATERSTON: The original ladders for DNA sequence, we actually. It's. horrendous. ROBERT KRULWICH: And we haven't mentioned the hardest part. Now. if you look inside you will find, of course, hundreds of millions of As, and. Cs, and Ts and Gs, but it turns out that only about one percent of them are. These are the genes that scientists are searching for. So. somewhere in this dense chemical forest are genes involved in deafness. Alzheimer's, cancer, cataracts. This is such a maze scientists need. But at the old pace that would take close to forever. ROBERT WATERSTON: C and then an A. ROBERT KRULWICH: And then came the revolution. In the last ten. years the entire process has been computerized. That cost hundreds of millions. But now, instead of decoding a few hundred letters by hand in a. ROBERT COOK- DEEGAN (National Research Council): This is something. Everybody, when the. Genome project was being born, was consciously aware of their role in. ROBERT KRULWICH: Getting the letters out is.. What's your. metaphor? ERIC LANDER: Oh, golly gee. I mean, you can have very high falutin'. This is basically a parts list. Blueprints. and all these fancy.. It's just a parts list. It's a parts list with a lot of. If you take an airplane, a Boeing 7. I think it has like 1. If I gave you a parts list for the Boeing 7. You'd know 1. 00,0. On the other hand, I bet you wouldn't know. And I bet you wouldn't know why it flies. Well we're in. the same boat. We now have a parts list. That's what the human genome project. If you want to understand the plane you. I mean he loved to. And this was later when he was. And so he and I. would just crack each other up. ROBERT KRULWICH: Hayden seemed to be developing normally for. Allison began to notice that some things were not. ALLISON LORD (Mother of son with Tay Sachs): I was very anxious. Hayden. I sensed that something was not the same. I would see. my friends changing the diaper of their child who was around the same age. Hayden didn't do that. ROBERT KRULWICH: Doctors told them that Hayden was just. But by the time he turned a year old, it was clear. He never crawled, he never talked, he never ate. TIM LORD: I remember the last time he laughed. We came back and I propped him up right here on the couch. I was sitting next to him and he just kind of threw his head back and. And that the last time he. That's really hard. ROBERT KRULWICH: It turned out that Hayden had Tay Sachs. DR. EDWIN KOLODNY (NYU, Department of Neurology): What happens is. So at six months a child should be turning. But since genes create proteins, that error creates a problem in. But. now the protein doesn't work. So fat builds up, swells the brain, and. And all of this is the. DNA. EDWIN KOLODNY: In most cases it's a single base change. As we say, a. letter difference. ROBERT KRULWICH: One defective letter out of three billion. TIM LORD: That's my boy. ROBERT KRULWICH: Tay Sachs is a relentlessly progressive. In the year since his diagnosis, Hayden has gone blind. He can't eat. solid food. It's harder and harder for him to swallow. He can't move on his own. And he has seizures as often as 1. DR. EDWIN KOLODNY: For children with classical Tay Sachs Disease. And children die by the age of five to seven. ROBERT KRULWICH: As it happens, Tim Lord has an identical twin. When Hayden was diagnosed, that brother, Charlie, went to New York to. Tim. And of course, Charlie called his wife Blyth to tell her the news. He called me on the phone and he told me. I went up into the computer and looked it up and then. I read. ROBERT KRULWICH: Blyth and Charlie had a three- year- old. Taylor, and a baby girl named Cameron. Cameron was healthy and happy. BLYTH LORD: On the NTSAD Website it talks about typically between six. And Hayden had always had a really heavy startle. But we had noticed that Cameron had a comparable startle response. It was exactly a week until we got the final results on Cameron's blood. And then the Tuesday before Thanksgiving we went into our pediatrician's. Blyth was a. carrier and that Cameron had Tay Sachs. BLYTH LORD: He said.. And even then, the baby. So even though there is a Tay. Sachs test, the Lords had no reason to think they would be at risk. And yet. incredibly, all four of them, Tim and Charlie and both their wives—all four. That was an unbelievably bad roll of the genetic. TIM LORD: Charlie and I are incredibly close and have been all our. And when I think about him and Blyth having to go through this, it just. It just seems too much. CHARLIE LORD: I had already geared myself up for being my brother's rock. I couldn't imagine having to help him and go through it myself. ROBERT KRULWICH: For families like the Lords, and for. Human Genome project offers the chance to find out early if. TIM LORD: I would like to see a really aggressive push to develop a test. And I think it's. Now that they've mapped the human genome, I mean, the. They're horrible. I think it's something. Jest ratunek dla Polski, je.
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